Nonergot dopamine-receptor agonists for treating Parkinson’s disease – a network meta-analysis
Identifieur interne : 000990 ( Main/Exploration ); précédent : 000989; suivant : 000991Nonergot dopamine-receptor agonists for treating Parkinson’s disease – a network meta-analysis
Auteurs : Kristian Thorlund [Canada, États-Unis] ; Ping Wu [Canada] ; Eric Druyts [Canada] ; Shawn Eapen [Canada] ; Edward J. Mills [États-Unis, Canada]Source :
- Neuropsychiatric Disease and Treatment [ 1176-6328 ] ; 2014.
Abstract
To compare the efficacy of the three nonergot dopamine-receptor agonists (DAs) pramipexole, ropinirole, and rotigotine for the treatment of early and advanced Parkinson’s disease (PD).
Bayesian network meta-analyses were performed separately for early and advanced PD, and at time points 11–16 and 24–28 weeks. Outcomes for early PD included improvement on the Unified Parkinson’s Disease Rating Scale (UPDRS) activities in daily life (UPDRS-II), motor function (UPDRS-III), and their subtotal (UPDRS-II + III). Outcomes for advanced PD also included daily “off time” (hours), but not UPDRS-II + III.
Totals of 23 and 24 trials informed early and advanced PD analyses. For early PD UPDRS-II at 11–16 weeks, pramipexole and rotigotine were statistically significantly superior to placebo, but ropinirole was not. For UPDRS-III and UPDRS-II + III, all DAs were statistically significantly better than placebo and exhibited similar improvements. At 24–28 weeks, results were also statistically significant for all DAs versus placebo, and the magnitudes of improvements were similar for pramipexole, ropinirole and rotigotine. Advanced PD improvements on UPDRS-II, UPRDS-III, and off time were statistically significant for pramipexole, ropinirole, and rotigotine versus placebo. At 11–16 weeks, rotigotine yielded slightly smaller effects than ropinirole and pramipexole, but credible intervals on differences were wide. For off time, results were near identical. At 24–28 weeks, results were similar for all three outcomes. Ropinirole yielded a slightly higher improvement on UPDRS-III, but a slightly smaller improvement in off time.
Our analyses suggest that pramipexole, ropinirole, and rotigotine exhibit similar efficacy in the treatment of early and advanced PD.
Url:
DOI: 10.2147/NDT.S60061
PubMed: 24855362
PubMed Central: 4019622
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000A54
- to stream Pmc, to step Curation: 000A54
- to stream Pmc, to step Checkpoint: 000437
- to stream Ncbi, to step Merge: 001768
- to stream Ncbi, to step Curation: 001768
- to stream Ncbi, to step Checkpoint: 001768
- to stream Main, to step Merge: 000992
- to stream Main, to step Curation: 000990
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Nonergot dopamine-receptor agonists for treating Parkinson’s disease – a network meta-analysis</title><author><name sortKey="Thorlund, Kristian" sort="Thorlund, Kristian" uniqKey="Thorlund K" first="Kristian" last="Thorlund">Kristian Thorlund</name><affiliation wicri:level="4"><nlm:aff id="af1-ndt-10-767">Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON</wicri:regionArea><orgName type="university">Université McMaster</orgName><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-ndt-10-767">Stanford Prevention Research Center, Stanford University, Stanford, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Stanford Prevention Research Center, Stanford University, Stanford, CA</wicri:regionArea><wicri:noRegion>CA</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af4-ndt-10-767">Redwood Outcomes, Vancouver, BC, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Redwood Outcomes, Vancouver, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Ping" sort="Wu, Ping" uniqKey="Wu P" first="Ping" last="Wu">Ping Wu</name><affiliation wicri:level="1"><nlm:aff id="af3-ndt-10-767">Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Faculty of Health Sciences, University of Ottawa, Ottawa, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af4-ndt-10-767">Redwood Outcomes, Vancouver, BC, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Redwood Outcomes, Vancouver, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author><author><name sortKey="Druyts, Eric" sort="Druyts, Eric" uniqKey="Druyts E" first="Eric" last="Druyts">Eric Druyts</name><affiliation wicri:level="1"><nlm:aff id="af3-ndt-10-767">Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Faculty of Health Sciences, University of Ottawa, Ottawa, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af4-ndt-10-767">Redwood Outcomes, Vancouver, BC, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Redwood Outcomes, Vancouver, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author><author><name sortKey="Eapen, Shawn" sort="Eapen, Shawn" uniqKey="Eapen S" first="Shawn" last="Eapen">Shawn Eapen</name><affiliation wicri:level="1"><nlm:aff id="af3-ndt-10-767">Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Faculty of Health Sciences, University of Ottawa, Ottawa, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af4-ndt-10-767">Redwood Outcomes, Vancouver, BC, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Redwood Outcomes, Vancouver, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author><author><name sortKey="Mills, Edward J" sort="Mills, Edward J" uniqKey="Mills E" first="Edward J" last="Mills">Edward J. Mills</name><affiliation wicri:level="1"><nlm:aff id="af2-ndt-10-767">Stanford Prevention Research Center, Stanford University, Stanford, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Stanford Prevention Research Center, Stanford University, Stanford, CA</wicri:regionArea><wicri:noRegion>CA</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af3-ndt-10-767">Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Faculty of Health Sciences, University of Ottawa, Ottawa, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af4-ndt-10-767">Redwood Outcomes, Vancouver, BC, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Redwood Outcomes, Vancouver, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24855362</idno><idno type="pmc">4019622</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019622</idno><idno type="RBID">PMC:4019622</idno><idno type="doi">10.2147/NDT.S60061</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000A54</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A54</idno><idno type="wicri:Area/Pmc/Curation">000A54</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000A54</idno><idno type="wicri:Area/Pmc/Checkpoint">000437</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000437</idno><idno type="wicri:Area/Ncbi/Merge">001768</idno><idno type="wicri:Area/Ncbi/Curation">001768</idno><idno type="wicri:Area/Ncbi/Checkpoint">001768</idno><idno type="wicri:doubleKey">1176-6328:2014:Thorlund K:nonergot:dopamine:receptor</idno><idno type="wicri:Area/Main/Merge">000992</idno><idno type="wicri:Area/Main/Curation">000990</idno><idno type="wicri:Area/Main/Exploration">000990</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Nonergot dopamine-receptor agonists for treating Parkinson’s disease – a network meta-analysis</title><author><name sortKey="Thorlund, Kristian" sort="Thorlund, Kristian" uniqKey="Thorlund K" first="Kristian" last="Thorlund">Kristian Thorlund</name><affiliation wicri:level="4"><nlm:aff id="af1-ndt-10-767">Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON</wicri:regionArea><orgName type="university">Université McMaster</orgName><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-ndt-10-767">Stanford Prevention Research Center, Stanford University, Stanford, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Stanford Prevention Research Center, Stanford University, Stanford, CA</wicri:regionArea><wicri:noRegion>CA</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af4-ndt-10-767">Redwood Outcomes, Vancouver, BC, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Redwood Outcomes, Vancouver, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Ping" sort="Wu, Ping" uniqKey="Wu P" first="Ping" last="Wu">Ping Wu</name><affiliation wicri:level="1"><nlm:aff id="af3-ndt-10-767">Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Faculty of Health Sciences, University of Ottawa, Ottawa, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af4-ndt-10-767">Redwood Outcomes, Vancouver, BC, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Redwood Outcomes, Vancouver, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author><author><name sortKey="Druyts, Eric" sort="Druyts, Eric" uniqKey="Druyts E" first="Eric" last="Druyts">Eric Druyts</name><affiliation wicri:level="1"><nlm:aff id="af3-ndt-10-767">Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Faculty of Health Sciences, University of Ottawa, Ottawa, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af4-ndt-10-767">Redwood Outcomes, Vancouver, BC, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Redwood Outcomes, Vancouver, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author><author><name sortKey="Eapen, Shawn" sort="Eapen, Shawn" uniqKey="Eapen S" first="Shawn" last="Eapen">Shawn Eapen</name><affiliation wicri:level="1"><nlm:aff id="af3-ndt-10-767">Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Faculty of Health Sciences, University of Ottawa, Ottawa, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af4-ndt-10-767">Redwood Outcomes, Vancouver, BC, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Redwood Outcomes, Vancouver, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author><author><name sortKey="Mills, Edward J" sort="Mills, Edward J" uniqKey="Mills E" first="Edward J" last="Mills">Edward J. Mills</name><affiliation wicri:level="1"><nlm:aff id="af2-ndt-10-767">Stanford Prevention Research Center, Stanford University, Stanford, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Stanford Prevention Research Center, Stanford University, Stanford, CA</wicri:regionArea><wicri:noRegion>CA</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af3-ndt-10-767">Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Faculty of Health Sciences, University of Ottawa, Ottawa, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af4-ndt-10-767">Redwood Outcomes, Vancouver, BC, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Redwood Outcomes, Vancouver, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author></analytic><series><title level="j">Neuropsychiatric Disease and Treatment</title><idno type="ISSN">1176-6328</idno><idno type="eISSN">1178-2021</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objective</title><p>To compare the efficacy of the three nonergot dopamine-receptor agonists (DAs) pramipexole, ropinirole, and rotigotine for the treatment of early and advanced Parkinson’s disease (PD).</p></sec><sec><title>Materials and methods</title><p>Bayesian network meta-analyses were performed separately for early and advanced PD, and at time points 11–16 and 24–28 weeks. Outcomes for early PD included improvement on the Unified Parkinson’s Disease Rating Scale (UPDRS) activities in daily life (UPDRS-II), motor function (UPDRS-III), and their subtotal (UPDRS-II + III). Outcomes for advanced PD also included daily “off time” (hours), but not UPDRS-II + III.</p></sec><sec><title>Results</title><p>Totals of 23 and 24 trials informed early and advanced PD analyses. For early PD UPDRS-II at 11–16 weeks, pramipexole and rotigotine were statistically significantly superior to placebo, but ropinirole was not. For UPDRS-III and UPDRS-II + III, all DAs were statistically significantly better than placebo and exhibited similar improvements. At 24–28 weeks, results were also statistically significant for all DAs versus placebo, and the magnitudes of improvements were similar for pramipexole, ropinirole and rotigotine. Advanced PD improvements on UPDRS-II, UPRDS-III, and off time were statistically significant for pramipexole, ropinirole, and rotigotine versus placebo. At 11–16 weeks, rotigotine yielded slightly smaller effects than ropinirole and pramipexole, but credible intervals on differences were wide. For off time, results were near identical. At 24–28 weeks, results were similar for all three outcomes. Ropinirole yielded a slightly higher improvement on UPDRS-III, but a slightly smaller improvement in off time.</p></sec><sec><title>Conclusion</title><p>Our analyses suggest that pramipexole, ropinirole, and rotigotine exhibit similar efficacy in the treatment of early and advanced PD.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Sweet, Rd" uniqKey="Sweet R">RD Sweet</name></author><author><name sortKey="Mcdowell, Fh" uniqKey="Mcdowell F">FH McDowell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lesser, Rp" uniqKey="Lesser R">RP Lesser</name></author><author><name sortKey="Fahn, S" uniqKey="Fahn S">S Fahn</name></author><author><name sortKey="Snider, Sr" uniqKey="Snider S">SR Snider</name></author><author><name sortKey="Cote, Lj" uniqKey="Cote L">LJ Cote</name></author><author><name sortKey="Isgreen, Wp" uniqKey="Isgreen W">WP Isgreen</name></author><author><name sortKey="Barrett, Re" uniqKey="Barrett R">RE Barrett</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Brooks, Dj" uniqKey="Brooks D">DJ Brooks</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Steiger, M" uniqKey="Steiger M">M Steiger</name></author><author><name sortKey="Jost, W" uniqKey="Jost W">W Jost</name></author><author><name sortKey="Grandas, F" uniqKey="Grandas F">F Grandas</name></author><author><name sortKey="Van Camp, G" uniqKey="Van Camp G">G Van Camp</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kulisevsky, J" uniqKey="Kulisevsky J">J Kulisevsky</name></author><author><name sortKey="Pagonabarraga, J" uniqKey="Pagonabarraga J">J Pagonabarraga</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leentjens, Af" uniqKey="Leentjens A">AF Leentjens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, G" uniqKey="Lu G">G Lu</name></author><author><name sortKey="Ades, Ae" uniqKey="Ades A">AE Ades</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dias, S" uniqKey="Dias S">S Dias</name></author><author><name sortKey="Welton, N" uniqKey="Welton N">N Welton</name></author><author><name sortKey="Sutton, A" uniqKey="Sutton A">A Sutton</name></author><author><name sortKey="Ades, A" uniqKey="Ades A">A Ades</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mills, Ej" uniqKey="Mills E">EJ Mills</name></author><author><name sortKey="Ioannidis, Jp" uniqKey="Ioannidis J">JP Ioannidis</name></author><author><name sortKey="Thorlund, K" uniqKey="Thorlund K">K Thorlund</name></author><author><name sortKey="Schunemann, Hj" uniqKey="Schunemann H">HJ Schunemann</name></author><author><name sortKey="Puhan, Ma" uniqKey="Puhan M">MA Puhan</name></author><author><name sortKey="Guyatt, Gh" uniqKey="Guyatt G">GH Guyatt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lunn, D" uniqKey="Lunn D">D Lunn</name></author><author><name sortKey="Spiegelhalter, D" uniqKey="Spiegelhalter D">D Spiegelhalter</name></author><author><name sortKey="Thomas, A" uniqKey="Thomas A">A Thomas</name></author><author><name sortKey="Best, N" uniqKey="Best N">N Best</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Giladi, N" uniqKey="Giladi N">N Giladi</name></author><author><name sortKey="Boroojerdi, B" uniqKey="Boroojerdi B">B Boroojerdi</name></author><author><name sortKey="Korczyn, Ad" uniqKey="Korczyn A">AD Korczyn</name></author><author><name sortKey="Burn, Dj" uniqKey="Burn D">DJ Burn</name></author><author><name sortKey="Clarke, Ce" uniqKey="Clarke C">CE Clarke</name></author><author><name sortKey="Schapira, Ah" uniqKey="Schapira A">AH Schapira</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rascol, O" uniqKey="Rascol O">O Rascol</name></author><author><name sortKey="Brooks, Dj" uniqKey="Brooks D">DJ Brooks</name></author><author><name sortKey="Korczyn, Ad" uniqKey="Korczyn A">AD Korczyn</name></author><author><name sortKey="De Deyn, Pp" uniqKey="De Deyn P">PP De Deyn</name></author><author><name sortKey="Clarke, Ce" uniqKey="Clarke C">CE Clarke</name></author><author><name sortKey="Lang, Ae" uniqKey="Lang A">AE Lang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Singer, C" uniqKey="Singer C">C Singer</name></author><author><name sortKey="Lamb, J" uniqKey="Lamb J">J Lamb</name></author><author><name sortKey="Ellis, A" uniqKey="Ellis A">A Ellis</name></author><author><name sortKey="Layton, G" uniqKey="Layton G">G Layton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Watts, Rl" uniqKey="Watts R">RL Watts</name></author><author><name sortKey="Lyons, Ke" uniqKey="Lyons K">KE Lyons</name></author><author><name sortKey="Pahwa, R" uniqKey="Pahwa R">R Pahwa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mizuno, Y" uniqKey="Mizuno Y">Y Mizuno</name></author><author><name sortKey="Kondo, T" uniqKey="Kondo T">T Kondo</name></author><author><name sortKey="Hasegawa, K" uniqKey="Hasegawa K">K Hasegawa</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Shannon, Km" uniqKey="Shannon K">KM Shannon</name></author><author><name sortKey="Bennett, Jp" uniqKey="Bennett J">JP Bennett</name></author><author><name sortKey="Friedman, Jh" uniqKey="Friedman J">JH Friedman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kulisevsky, J" uniqKey="Kulisevsky J">J Kulisevsky</name></author><author><name sortKey="L Pez Villegas, D" uniqKey="L Pez Villegas D">D López-Villegas</name></author><author><name sortKey="Garcia Sanchez, C" uniqKey="Garcia Sanchez C">C García-Sánchez</name></author><author><name sortKey="Barbanoj, M" uniqKey="Barbanoj M">M Barbanoj</name></author><author><name sortKey="Gironell, A" uniqKey="Gironell A">A Gironell</name></author><author><name sortKey="Pascual Sedano, B" uniqKey="Pascual Sedano B">B Pascual-Sedano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barone, P" uniqKey="Barone P">P Barone</name></author><author><name sortKey="Bravi, D" uniqKey="Bravi D">D Bravi</name></author><author><name sortKey="Bermejo Pareja, F" uniqKey="Bermejo Pareja F">F Bermejo-Pareja</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barone, P" uniqKey="Barone P">P Barone</name></author><author><name sortKey="Poewe, W" uniqKey="Poewe W">W Poewe</name></author><author><name sortKey="Albrecht, S" uniqKey="Albrecht S">S Albrecht</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wong, Ks" uniqKey="Wong K">KS Wong</name></author><author><name sortKey="Lu, Cs" uniqKey="Lu C">CS Lu</name></author><author><name sortKey="Shan, De" uniqKey="Shan D">DE Shan</name></author><author><name sortKey="Yang, Cc" uniqKey="Yang C">CC Yang</name></author><author><name sortKey="Tsoi, Th" uniqKey="Tsoi T">TH Tsoi</name></author><author><name sortKey="Mok, V" uniqKey="Mok V">V Mok</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kieburtz, K" uniqKey="Kieburtz K">K Kieburtz</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Thomas, A" uniqKey="Thomas A">A Thomas</name></author><author><name sortKey="Bonanni, L" uniqKey="Bonanni L">L Bonanni</name></author><author><name sortKey="Di Iorio, A" uniqKey="Di Iorio A">A Di Iorio</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Poewe, W" uniqKey="Poewe W">W Poewe</name></author><author><name sortKey="Rascol, O" uniqKey="Rascol O">O Rascol</name></author><author><name sortKey="Barone, P" uniqKey="Barone P">P Barone</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sampaio, C" uniqKey="Sampaio C">C Sampaio</name></author><author><name sortKey="Bronzova, J" uniqKey="Bronzova J">J Bronzova</name></author><author><name sortKey="Hauser, Ra" uniqKey="Hauser R">RA Hauser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jankovic, J" uniqKey="Jankovic J">J Jankovic</name></author><author><name sortKey="Watts, Rl" uniqKey="Watts R">RL Watts</name></author><author><name sortKey="Martin, W" uniqKey="Martin W">W Martin</name></author><author><name sortKey="Boroojerdi, B" uniqKey="Boroojerdi B">B Boroojerdi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hauser, Ra" uniqKey="Hauser R">RA Hauser</name></author><author><name sortKey="Schapira, Ah" uniqKey="Schapira A">AH Schapira</name></author><author><name sortKey="Rascol, O" uniqKey="Rascol O">O Rascol</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brooks, Dj" uniqKey="Brooks D">DJ Brooks</name></author><author><name sortKey="Abbott, Rj" uniqKey="Abbott R">RJ Abbott</name></author><author><name sortKey="Lees, Aj" uniqKey="Lees A">AJ Lees</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Whone, Al" uniqKey="Whone A">AL Whone</name></author><author><name sortKey="Watts, Rl" uniqKey="Watts R">RL Watts</name></author><author><name sortKey="Stoessl, Aj" uniqKey="Stoessl A">AJ Stoessl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oertel, Wh" uniqKey="Oertel W">WH Oertel</name></author><author><name sortKey="Wolters, E" uniqKey="Wolters E">E Wolters</name></author><author><name sortKey="Sampaio, C" uniqKey="Sampaio C">C Sampaio</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Navan, P" uniqKey="Navan P">P Navan</name></author><author><name sortKey="Findley, Lj" uniqKey="Findley L">LJ Findley</name></author><author><name sortKey="Jeffs, Ja" uniqKey="Jeffs J">JA Jeffs</name></author><author><name sortKey="Pearce, Rk" uniqKey="Pearce R">RK Pearce</name></author><author><name sortKey="Bain, Pg" uniqKey="Bain P">PG Bain</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Korczyn, Ad" uniqKey="Korczyn A">AD Korczyn</name></author><author><name sortKey="Brunt, Er" uniqKey="Brunt E">ER Brunt</name></author><author><name sortKey="Larsen, Jp" uniqKey="Larsen J">JP Larsen</name></author><author><name sortKey="Nagy, Z" uniqKey="Nagy Z">Z Nagy</name></author><author><name sortKey="Poewe, Wh" uniqKey="Poewe W">WH Poewe</name></author><author><name sortKey="Ruggieri, S" uniqKey="Ruggieri S">S Ruggieri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Adler, Ch" uniqKey="Adler C">CH Adler</name></author><author><name sortKey="Sethi, Kd" uniqKey="Sethi K">KD Sethi</name></author><author><name sortKey="Hauser, Ra" uniqKey="Hauser R">RA Hauser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Poewe, Wh" uniqKey="Poewe W">WH Poewe</name></author><author><name sortKey="Rascol, O" uniqKey="Rascol O">O Rascol</name></author><author><name sortKey="Quinn, N" uniqKey="Quinn N">N Quinn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koller, W" uniqKey="Koller W">W Koller</name></author><author><name sortKey="Lees, A" uniqKey="Lees A">A Lees</name></author><author><name sortKey="Doder, M" uniqKey="Doder M">M Doder</name></author><author><name sortKey="Hely, M" uniqKey="Hely M">M Hely</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lieberman, A" uniqKey="Lieberman A">A Lieberman</name></author><author><name sortKey="Olanow, Cw" uniqKey="Olanow C">CW Olanow</name></author><author><name sortKey="Sethi, K" uniqKey="Sethi K">K Sethi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pinter, Mm" uniqKey="Pinter M">MM Pinter</name></author><author><name sortKey="Pogarell, O" uniqKey="Pogarell O">O Pogarell</name></author><author><name sortKey="Oertel, Wh" uniqKey="Oertel W">WH Oertel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schapira, Ah" uniqKey="Schapira A">AH Schapira</name></author><author><name sortKey="Barone, P" uniqKey="Barone P">P Barone</name></author><author><name sortKey="Hauser, Ra" uniqKey="Hauser R">RA Hauser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mizuno, Y" uniqKey="Mizuno Y">Y Mizuno</name></author><author><name sortKey="Yanagisawa, N" uniqKey="Yanagisawa N">N Yanagisawa</name></author><author><name sortKey="Kuno, S" uniqKey="Kuno S">S Kuno</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lieberman, A" uniqKey="Lieberman A">A Lieberman</name></author><author><name sortKey="Ranhosky, A" uniqKey="Ranhosky A">A Ranhosky</name></author><author><name sortKey="Korts, D" uniqKey="Korts D">D Korts</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hutton, Jt" uniqKey="Hutton J">JT Hutton</name></author><author><name sortKey="Koller, Wc" uniqKey="Koller W">WC Koller</name></author><author><name sortKey="Ahlskog, Je" uniqKey="Ahlskog J">JE Ahlskog</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mizuno, Y" uniqKey="Mizuno Y">Y Mizuno</name></author><author><name sortKey="Abe, T" uniqKey="Abe T">T Abe</name></author><author><name sortKey="Hasegawa, K" uniqKey="Hasegawa K">K Hasegawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Trenkwalder, C" uniqKey="Trenkwalder C">C Trenkwalder</name></author><author><name sortKey="Kies, B" uniqKey="Kies B">B Kies</name></author><author><name sortKey="Rudzinska, M" uniqKey="Rudzinska M">M Rudzinska</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pahwa, R" uniqKey="Pahwa R">R Pahwa</name></author><author><name sortKey="Stacy, Ma" uniqKey="Stacy M">MA Stacy</name></author><author><name sortKey="Factor, Sa" uniqKey="Factor S">SA Factor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barone, P" uniqKey="Barone P">P Barone</name></author><author><name sortKey="Lamb, J" uniqKey="Lamb J">J Lamb</name></author><author><name sortKey="Ellis, A" uniqKey="Ellis A">A Ellis</name></author><author><name sortKey="Clarke, Z" uniqKey="Clarke Z">Z Clarke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guttman, M" uniqKey="Guttman M">M Guttman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moller, Jc" uniqKey="Moller J">JC Möller</name></author><author><name sortKey="Oertel, Wh" uniqKey="Oertel W">WH Oertel</name></author><author><name sortKey="Koster, J" uniqKey="Koster J">J Köster</name></author><author><name sortKey="Pezzoli, G" uniqKey="Pezzoli G">G Pezzoli</name></author><author><name sortKey="Provinciali, L" uniqKey="Provinciali L">L Provinciali</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lewitt, Pa" uniqKey="Lewitt P">PA LeWitt</name></author><author><name sortKey="Lyons, Ke" uniqKey="Lyons K">KE Lyons</name></author><author><name sortKey="Pahwa, R" uniqKey="Pahwa R">R Pahwa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Im, Jh" uniqKey="Im J">JH Im</name></author><author><name sortKey="Ha, Jh" uniqKey="Ha J">JH Ha</name></author><author><name sortKey="Cho, Is" uniqKey="Cho I">IS Cho</name></author><author><name sortKey="Lee, Mc" uniqKey="Lee M">MC Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Inzelberg, R" uniqKey="Inzelberg R">R Inzelberg</name></author><author><name sortKey="Nisipeanu, P" uniqKey="Nisipeanu P">P Nisipeanu</name></author><author><name sortKey="Rabey, Jm" uniqKey="Rabey J">JM Rabey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rektorova, I" uniqKey="Rektorova I">I Rektorová</name></author><author><name sortKey="Rektor, I" uniqKey="Rektor I">I Rektor</name></author><author><name sortKey="Bares, M" uniqKey="Bares M">M Bares</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brunt, Er" uniqKey="Brunt E">ER Brunt</name></author><author><name sortKey="Brooks, Dj" uniqKey="Brooks D">DJ Brooks</name></author><author><name sortKey="Korczyn, Ad" uniqKey="Korczyn A">AD Korczyn</name></author><author><name sortKey="Montastruc, Jl" uniqKey="Montastruc J">JL Montastruc</name></author><author><name sortKey="Stocchi, F" uniqKey="Stocchi F">F Stocchi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Steiger, Mj" uniqKey="Steiger M">MJ Steiger</name></author><author><name sortKey="El Debas, T" uniqKey="El Debas T">T El-Debas</name></author><author><name sortKey="Anderson, T" uniqKey="Anderson T">T Anderson</name></author><author><name sortKey="Findley, Lj" uniqKey="Findley L">LJ Findley</name></author><author><name sortKey="Marsden, Cd" uniqKey="Marsden C">CD Marsden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wermuth, L" uniqKey="Wermuth L">L Wermuth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rascol, O" uniqKey="Rascol O">O Rascol</name></author><author><name sortKey="Lees, Aj" uniqKey="Lees A">AJ Lees</name></author><author><name sortKey="Senard, Jm" uniqKey="Senard J">JM Senard</name></author><author><name sortKey="Pirtosek, Z" uniqKey="Pirtosek Z">Z Pirtosek</name></author><author><name sortKey="Montastruc, Jl" uniqKey="Montastruc J">JL Montastruc</name></author><author><name sortKey="Fuell, D" uniqKey="Fuell D">D Fuell</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Canada</li><li>États-Unis</li></country><region><li>Ontario</li></region><settlement><li>Hamilton (Ontario)</li></settlement><orgName><li>Université McMaster</li></orgName></list><tree><country name="Canada"><region name="Ontario"><name sortKey="Thorlund, Kristian" sort="Thorlund, Kristian" uniqKey="Thorlund K" first="Kristian" last="Thorlund">Kristian Thorlund</name></region><name sortKey="Druyts, Eric" sort="Druyts, Eric" uniqKey="Druyts E" first="Eric" last="Druyts">Eric Druyts</name><name sortKey="Druyts, Eric" sort="Druyts, Eric" uniqKey="Druyts E" first="Eric" last="Druyts">Eric Druyts</name><name sortKey="Eapen, Shawn" sort="Eapen, Shawn" uniqKey="Eapen S" first="Shawn" last="Eapen">Shawn Eapen</name><name sortKey="Eapen, Shawn" sort="Eapen, Shawn" uniqKey="Eapen S" first="Shawn" last="Eapen">Shawn Eapen</name><name sortKey="Mills, Edward J" sort="Mills, Edward J" uniqKey="Mills E" first="Edward J" last="Mills">Edward J. Mills</name><name sortKey="Mills, Edward J" sort="Mills, Edward J" uniqKey="Mills E" first="Edward J" last="Mills">Edward J. Mills</name><name sortKey="Thorlund, Kristian" sort="Thorlund, Kristian" uniqKey="Thorlund K" first="Kristian" last="Thorlund">Kristian Thorlund</name><name sortKey="Wu, Ping" sort="Wu, Ping" uniqKey="Wu P" first="Ping" last="Wu">Ping Wu</name><name sortKey="Wu, Ping" sort="Wu, Ping" uniqKey="Wu P" first="Ping" last="Wu">Ping Wu</name></country><country name="États-Unis"><noRegion><name sortKey="Thorlund, Kristian" sort="Thorlund, Kristian" uniqKey="Thorlund K" first="Kristian" last="Thorlund">Kristian Thorlund</name></noRegion><name sortKey="Mills, Edward J" sort="Mills, Edward J" uniqKey="Mills E" first="Edward J" last="Mills">Edward J. Mills</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000990 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000990 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4019622
|texte= Nonergot dopamine-receptor agonists for treating Parkinson’s disease – a network meta-analysis
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:24855362" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |